Newcastle Laboratories

Dr Barry John Toole

Barry Toole

Blood sciences

Clinical Biochemist

Principal Clinical Biochemist – Blood Sciences

Qualifications: BSc, MSc, PhD, FRCPath

Office Location: Freeman Hospital

Barry obtained his Honours degree in Biochemistry from the University of Newcastle upon Tyne followed by a PhD in diabetes research from the Medical Research Council, Dundee University. He obtained an MSc in clinical biochemistry when training in North Glasgow hospitals and was appointed Principal Clinical Biochemist within Newcastle upon Tyne hospitals, where he has since completed FRCPath examinations.


His interests include the provision and development of specialist chemistry services, including biogenic amines, immunosuppressant’s, vitamins and trace elements, and TPMT.


Emms H, Farah G, Shine B, Boot C, Toole B, McFadden M, Lam L, Ou ZQ, Woollard G, Madhavaram H, Kyle C, Grossman AB. Falsely elevated plasma metanephrine in patients taking midodrine. Ann Clin Biochem (2018); 55: 509-515.


Boot C, Toole B, Johnson SJ, Ball S, Neely D. Single-centre study of the diagnosic performance of plasma metanephrines with seated sampling for the diagnosis of phaeochromocytoma/paraganglioma. Ann Clin Biochem (2017); 54: 143-148.


Toole B, Gechtman C, Dreier J, Kuhn J, Gutierrez MR, Barrett A, Niederau C. Evaluation of the new cyclosporine and tacrolimus automated electrochemiluminescence immunoassay under field conditions. Clin Lab (2015); 61: 1303-15.


Reid D, Toole BJ, Knox S, Talwar D, Harten J, O’Reilly DS, Blackwell S, Kinsella J, McMillan DC, Wallace AM. The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty. Am J Clin Nutr (2011) May; 93(5), 1006-1011.


Dorrian CA, Toole BJ, Alvarez-Madrazo S, Kelly A, Connell JM, Wallace AM. A screening procedure for primary aldosteronism based on the Diasorin Liaison automated chemiluminescent immunoassay for direct renin. Ann Clin Biochem (2010) May; 47, 195-199.


Toole BJ, Cohen PT. The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. Cell Signal (2007) May; 19(5), 1044-1055.


Armstrong JL, Bonavaud SM, Toole BJ, Yeaman SJ. Regulation of glycogen synthesis by amino acids in cultured human muscle cells. J Biol Chem (2001) Jan; 276(2), 952-956.